Carbon monoxide binds to hemoglobin and shifts the oxyhemoglobin curve to the left, preventing oxygen from being released into the tissues. Thus, it can cause chemical anemia. Elevated levels of cardiac markers such as troponin may be seen when myocardial damage occurs. Electrocardiographic or echocardiographic changes can be monitored. To explain this damage in the myocardium, the toxic effect of carbon monoxide binding to myoglobin is also mentioned in addition to the oxidative stress of carboxyhemoglobin. Carbon monoxide-bound myoglobin is not capable of delivering sufficient oxygen to the myocardium.
Karbon monoksit hemoglobine bağlanır ve oksihemoglobin eğrisini sola kaydırarak oksijenin dokulara salınmasını engeller. Böylece kimyasal anemiye neden olabilir. Miyokardiyal hasar meydana geldiğinde troponin gibi yüksek kardiyak belirteç seviyeleri görülebilir. Elektrokardiyografik veya ekokardiyografik değişiklikler izlenebilir. Miyokarddaki bu hasarı açıklamak için karboksihemoglobinin oksidatif stresine ek olarak karbon monoksitin miyoglobine bağlanmasının toksik etkisinden de bahsedilmiştir. Karbon monoksite bağlı miyoglobin, miyokardiyuma yeterli oksijen sunamamaktadır.
Primary Language | English |
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Subjects | Emergency Medicine |
Journal Section | Letter To The Editor |
Authors |
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Publication Date | July 1, 2022 |
Submission Date | December 4, 2021 |
Acceptance Date | February 3, 2022 |
Published in Issue | Year 2022Volume: 4 Issue: 2 |
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